KinExA 4000
Kinetics, affinity, and concentration analysis in one system.
Highly sensitive affinity and kinetics characterization of antibodies, cells (native and engineered), small molecules, molecules in unpurified samples, and unmodified molecules in solution. The determination of binding kinetics and affinity plays a critical role in selecting candidates for therapeutics development. KinExA 4000 measurements require low sample volumes and are performed in physiologically relevant conditions. KinExA has the ability to measure high affinity interactions, allowing users to accurately measure their strongest candidates. The KinExA 4000 is an easy to use platform with intuitive, single click analysis, software that gives users confidence in their data and candidates. Schedule a presentation or demonstration with one of our scientists to learn more. |
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| KinExA 4000 | Details |
|---|---|
| Applications | Affinity & Kinetics Determination, Concentration Analysis |
| Included with Purchase | KinExA 4000 Instrument, One Year Instrument Warranty, 10 Year LED Warranty, KinExA Pro Software with [2] Licenses, Installation & Custom Training, GxP Support |
| Automation | Accommodates up to [4] distinct solid phase preparations and, in conjunction with up to 270 samples, supports lengthy periods of autonomous operation. |
| Measure | Antibodies, Cells, Small Molecules, Proteins, DNA, Lipids, Viruses, Serum, & More |
| Analysis | With a single click using KinExA Pro Software, exact solutions to the binding equations are used to fit the theoretical binding curve to experimental data. 95% confidence intervals are included in the analysis, giving users an additional layer of confidence in results. |
| Measurement Range | fM to nM |
| Maintenance Costs | Features an updated plumbing package that reduces maintenance costs (compared to the KinExA 3200) and fits into the side panel of the instrument. Extended warranty and custom maintenance plans are available for an additional fee. |
| Consumables | Overall cost of consumables is low when compared to similar platforms. Basic lab items such as 1xPBS and sample tubes are used in each run and can be sourced from most lab vendors. Unique bead types can be purchased from Sapidyne or other vendors. Flow cells are replaced as needed but typically last a few hundred experiments before requiring replacement and can be purchased from Sapidyne. |
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Selection Guide
| KinExA 3100 | KinExA 3200 | KinExA 4000 | |
|---|---|---|---|
| Kinetics & Affinity Characterization | ♦ | ♦ | ♦ |
| Concentration Analysis | ♦ | ♦ | ♦ |
| KinExA Pro Software | ♦ | ♦ | ♦ | Training & Warranty | ♦ | ♦ | ♦ |
| Fluorescence Detection Optics | ♦ | ♦ | ♦ |
| Interchangeable Filters | ♦ | ♦ | ♦ |
| Patented Flow Cell | ♦ | ♦ | ♦ |
| Pressure Transducer | ♦ | ♦ | ♦ |
| FDA 21 CFR Part 11 Compatible (1) | ♦ | ♦ | ♦ |
| Flow Cell Camera | ♦ | ♦ | |
| Internal Instrument Controller | ♦ | ♦ | |
| Autosampler Compatible | ♦ | (2) | |
| Experiment Queuing | (3) | ♦ | |
| Enclosed Sample Area | ♦ | ||
| LED Light Source | ♦ | ||
| Reduced Maintenance Costs | ♦ | ||
| Reduced Material Usage | ♦ | ||
| Temperature Recording | ♦ |
